Serum creatinine levels for hyperuricemic patients.

(A) Serum creatinine levels for hyperuricemic patients who received rasburicase (n = 10). All serum creatinine levels for patients were plotted in reference to initiation of study drug. No patients received assisted renal support, including a 15-year-old girl whose creatinine level was more than 2 mg/dL at baseline (see text for details). (B) Serum creatinine levels for hyperuricemic patients who received allopurinol (n = 9). All serum creatinine levels for patients were plotted in reference to initiation of study drug. One patient who began therapy with a normal creatinine for age developed renal failure requiring hemodialysis and hemofiltration for several days (see text for details). (C) Adjusted creatinine levels (percent ± SE of age/sex defined mean) for patients who were hyperuricemic at presentation. Squares denote patients who received rasburicase and stars represent allopurinol. Each creatinine level was adjusted by dividing the serum creatinine value by the published mean creatinine for patient's age and gender × 100%. Normal mean creatinine levels were the following: less than 1 year = 0.3 mg/dL; 1 to 12 years = 0.5 mg/dL; 12 to 16 years = 0.75 mg/dL; males 16 years or older = 0.95 mg/dL, females 16 years or older = 0.85 mg/dL.20 The adjusted creatinine declined steadily during initiation of chemotherapy only for the rasburicase group.