The degree of correction of anemia in β-thalassemic/normal hematopoietic chimeras as a function of the level of genetically normal HSC engraftment.

The PB Hb concentration is shown for each of the groups of animals shown in Figure 1 that are characterized by the indicated level of genetically normal HSC engraftment: Group 1 (transplanted with β-thalassemic BM alone; n = 8), 0%; group 2, 10.0%; group 3, 19.9%; group 4, 30.2%; group 5, 46.2%; and group 6, 100%. Group 7 (n = 5) represents a cohort of mice transplanted with 100% genetically normal Ly-5.1 BM cells. The data represent the mean and SEM of Hb concentration for each group. Groups 2 through 7 all differ significantly in Hb from group 1 (Pat least < .003). Groups 5, 6, and 7 did not significantly differ from one another (P > .25).