Log-scale used throughout. (A) Mean normal BM relative to germline VH (rearrangeable), germline VH (functional), or mean normal PB. (B) Mean normal PB relative to germline VH (functional). (C) Adult B-lineage ALL relative to mean normal BM or germline VH (rearrangeable). (D) Adult cALL relative to mean normal BM or germline VH (rearrangeable). (E) Adult pre-B ALL relative to mean normal BM or germline VH (rearrangeable). (F) Childhood B-lineage ALL relative to mean normal BM or germline VH (rearrangeable). (G) B-cell lymphoma relative to mean normal PB and germline VH(functional). (H) CLL relative to mean normal PB and germline VH (functional). ▭, VH1;, VH2;, VH3;, VH4;, VH5;, VH6.