Fig. 2.
![Fig. 2. Fever-range WBH stimulates lymphocyte adhesion to PNAd and MAdCAM-1 on HEV. / Splenic lymphocytes were isolated from BALB/c mice treated for 6 hours with WBH and from normothermic mice. The cells were then tested for adhesion to PLN and PP HEV (tissues from non–heat-treated mice) in a frozen-section adhesion assay under mechanical shear conditions. The specificity of lymphocyte-HEV adhesion was determined using the indicated function-blocking mAbs. Values represent the mean ± SE of 3 independent experiments. The differences between adhesion of splenocytes from normothermic control mice and WBH-treated mice were significant (P < .0001 [*] by unpaired 2-tailed Studentt test).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/9/10.1182_blood.v97.9.2727/6/h80910963002.jpeg?Expires=1735845154&Signature=DCo3rTpF1jiKmPNqdvFPxRWHuaE2FAW~EnjgA4F5mgabXEseXxIXxS7L6MwsUL5SlGgYHfWs2zqQ2rzOrqmdcQJ8kr~a-6O-8sAcd4Bv8k1Sv8LcSaxSd0C9C6DVyxpwMpMEAZ6MH0aixiQ5Ywh-OIP1Pr2zHdKoqc52ZlganOz2JRNgdYhF3S3p-SvM5yZVY7tQk9ny9KWYusETT36SD8ADbM-9a5S1kGJhRh~HsWdJIqSjycZndhhjYYd~5PM~2xNFevBZih17-3BSMfJaVpKi56aiUeMEKdheAFTT1yUAuF6nrzfXXltJA3Cyy882~TU-Cu04ZFy~lt4wJ53hYQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fever-range WBH stimulates lymphocyte adhesion to PNAd and MAdCAM-1 on HEV.
Splenic lymphocytes were isolated from BALB/c mice treated for 6 hours with WBH and from normothermic mice. The cells were then tested for adhesion to PLN and PP HEV (tissues from non–heat-treated mice) in a frozen-section adhesion assay under mechanical shear conditions. The specificity of lymphocyte-HEV adhesion was determined using the indicated function-blocking mAbs. Values represent the mean ± SE of 3 independent experiments. The differences between adhesion of splenocytes from normothermic control mice and WBH-treated mice were significant (P < .0001 [*] by unpaired 2-tailed Studentt test).
