Fig. 5.
Evi-1 requires CtBP as a corepressor for inhibition of TGF-β signaling.
(A) HepG2 cells were transfected with p3TP-Lux together with wild-type or each mutant of Evi-1 in the absence or the presence of 200 pM TGF-β as indicated. (B) Smad3, Smad4, and p3TP-Lux were transfected into HepG2 cells together with wild-type or each mutant of Evi-1 in the absence of TGF-β. Luciferase activities were assayed and presented as described in the legend for Figure 1.
