Modulation of Mylotarg by monocytes in vitro.

Monocytes were continuously incubated (open symbols; n = 5) or pulse labeled for 15 minutes (black symbols; n = 4) with Mylotarg in vitro. Saturation (circles) and modulation (squares) were analyzed at different time points during the continuous incubation (from start onward) or from the end of the 15-minute pulse labeling onward. Data are expressed as mean ± SD. Significant differences (P < .05; indicated by the asterisks) were observed for modulation or saturation between continuously incubated and pulse-labeled monocytes.