Fig. 2.
Binding of FXI and chimeric proteins to activated platelets.
FXI and FXI/PK chimeras were used in competition binding studies as competitive ligands for 22 nM 125I-FXI binding to activated platelets in the presence of 50 nM HK and 25 μM ZnCl2. Plasma-derived FXI (○), FXI/PKA3 (■), FXI/PKA4 (▵), and FXI/PKA4-Gly326 (⋄). Data are mean values (± SEM) of total binding results from 3 separate experiments, each performed in triplicate.
