MIP-1α enhances IL-6 stimulated osteoclast formation in human marrow cultures.

Long-term human marrow cultures were treated with varying concentrations of MIP-1α, IL-6, and a combination of IL-6 and MIP-1α. MIP-1α enhanced the effects of low (10 pg/mL) or high (100 pg/mL) concentrations of IL-6 on osteoclast formation. Results represent the mean ± SEM for quadruplicate determinations for a typical experiment. Similar results were seen in 3 independent experiments (*P < .05).