The influence of IL-10 on lymphocyte survival.

The percentage of apoptotic PBMCs, as measured by annexin-V staining, in 2 patients with ALPS (listed here as Pt 1 and 2, but these are not their ALPS family numbers) and the mean percentage (± SEM) of apoptotic cells of 3 healthy controls (HC), cultured with and without 400 ng/mL recombinant IL-10 and harvested after 0, 24, 28, or 72 hours. Annexin-V⁺ PBMCs represent the cumulative percentage of annexin-V⁺/propidium iodide (PI⁻) cells and annexin-V⁺/PI⁺ cells. ■, HC with IL-10; ○, HC without IL-10; ▪, Pt1 with IL-10; ♦, Pt1 without IL-10; ▴, Pt2 with IL-10; ●, Pt2 without IL-10.