Fig. 1.
Fig. 1. Overview of folate- and methionine-metabolizing pathways. / MTHFR catalyzes the reduction of 5,10-methylene THF to 5-methyl THF. Reduced activity of MTHFR results in the accumulation of 5,10-methylene THF, which accelerates methylation of dUMP to dTMP. MS catalyzes the transfer of the methyl base from 5-methyl THF to homocysteine. Reduced activity of MS leads to hypomethylation of DNA.

Overview of folate- and methionine-metabolizing pathways.

MTHFR catalyzes the reduction of 5,10-methylene THF to 5-methyl THF. Reduced activity of MTHFR results in the accumulation of 5,10-methylene THF, which accelerates methylation of dUMP to dTMP. MS catalyzes the transfer of the methyl base from 5-methyl THF to homocysteine. Reduced activity of MS leads to hypomethylation of DNA.

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