Fig. 7.
Enforced expression of ICSBP fails to down-regulate IRF-1 ISGF3γ or p21WAF1.
Immunoblot analysis of FA-C B lymphoblasts HSC536N (lane1), HSC536N transduced with the human ICSBP cDNA (HSC536N/ICSBP) (lane2), and HSC536N transduced with vector alone (HSC536N/neo) (lane 3) demonstrates that HSC536N/ICSBP are expressing high constitutive levels of ICSBP, but this expression fails to suppress IRF-1, ISGF3γ, or p21WAF1.