Antigen uptake by DCs.

BSA-FITC uptake at 37°C (shaded area) overlaid with the control uptake at 4°C (gray line) on day 5 (left panels) before TNF-α stimulation and on day 7 after TNF-α stimulation (right panels). Representative analysis of antigen uptake by DCs from a healthy donor (A), from a patient with chronic HCV infection (B), and from a patient whose HCV infection resolved (C). The difference in uptake (ΔMFI) on day 5 and day 7 for all persons is shown in panel D. Single symbols represent individuals: ■, healthy donor; ▪, patient with chronic HCV infection; ○, patient with resolved HCV infection. Horizontal bars represent group means. *P ≤ .03 for antigen uptake on day 7 between healthy donors and patients whose HCV infection resolved versus carriers of chronic HCV.