American Society of Hematology

Fig. 4.

$Fig. 4. Time-dependent changes in mitochondrial membrane potential and levels of ROS after imexon treatment. / The loss of mitochondrial membrane potential Δψm (A) and induction of ROS (B) in RPMI 8226 myeloma cells exposed to 180 μM imexon for various time periods. The fractions of cells that have high Δψm accumulate CMXRos, whereas the fraction of cells producing ROS is indicated by the enhanced fluorescence of the oxidized form of HE. Data represent mean ± SE of 3 experiments. The stars indicate statistically significant differences from control untreated cells (P < .05).$

Time-dependent changes in mitochondrial membrane potential and levels of ROS after imexon treatment.

The loss of mitochondrial membrane potential Δψ_m (A) and induction of ROS (B) in RPMI 8226 myeloma cells exposed to 180 μM imexon for various time periods. The fractions of cells that have high Δψ_m accumulate CMXRos, whereas the fraction of cells producing ROS is indicated by the enhanced fluorescence of the oxidized form of HE. Data represent mean ± SE of 3 experiments. The stars indicate statistically significant differences from control untreated cells (P < .05).

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