Age-dependent increase of the amount of sCD100 and autoantibodies in MRL/lpr mice.

Sera from MRL/lpr mice were collected at 8, 10, 12, 14, 16, 18, and 20 weeks of age. Concentrations of serum sCD100 (A) and titers of anti-ssDNA (B) were measured by ELISA as described in “Materials and methods.” The horizontal lines represent the mean value for each group. (C) Correlation was observed between the concentration of sCD100 and the titers of anti-ssDNA antibodies in 16-week-old MRL/lpr mice (n = 16) with a probability of P < .01.