Proposed differentiation pathways from HSC to DC.

The earliest CLPs and CMPs in bone marrow are capable of developing into DCs of both CD8α⁺ and CD8α⁻phenotypes. DC development potential is preserved in early T-cell progenitors and declines along with T-cell maturation as well as during granulocyte-macrophage commitment but is absent in B-cell progenitors and megakaryocyte-erythrocyte progenitors.