Fig. 6.
Fig. 6. Inhibition of Ca++ influx by the P2X1del receptor by purinergic receptor antagonists. / Peak Ca++ influx by 30 μM ADP (column 1) was inhibited by purinergic receptor antagonists. Adherent P2X1del-transfected cells were incubated with the indicated concentrations of SK&F 96365 (column 2, identified from the top), PPADS (columns 3 and 4), or suramin (column 5) before exposure to 30 μM ADP. Essentially identical patterns of inhibition were observed using 1 μM ADP (data not shown). Despite the alterations in the pharmacology of the expressed P2X1del receptor, inhibition by these antagonists was similar to that for the ATP-activated P2X1wt receptor (data not shown).

Inhibition of Ca++ influx by the P2X1del receptor by purinergic receptor antagonists.

Peak Ca++ influx by 30 μM ADP (column 1) was inhibited by purinergic receptor antagonists. Adherent P2X1del-transfected cells were incubated with the indicated concentrations of SK&F 96365 (column 2, identified from the top), PPADS (columns 3 and 4), or suramin (column 5) before exposure to 30 μM ADP. Essentially identical patterns of inhibition were observed using 1 μM ADP (data not shown). Despite the alterations in the pharmacology of the expressed P2X1del receptor, inhibition by these antagonists was similar to that for the ATP-activated P2X1wt receptor (data not shown).

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