TgZ expression in female reproductive tissues.

Stained with H&E (E,I) and X-gal (A-J). Whole-mount staining of the fourth inguinal mammary gland: (A) nontransgenic, (B) transgenic, (C) high-power image of the boxed region in (B) (TEB, terminal end buds), and (D) high-power image of portion of mammary gland from a 6-day pregnant transgenic mouse, showing positive staining of the ducts in the transgenic tissues. Note increased intensity of staining of blood vessels (BV) and lymph node (LN) in transgenic (B-D) compared with nontransgenic (A) tissue. (E-H) Uteri of nonpregnant (E, F) and 6-day pregnant (G, H) mice and the presence of positive cells in the myometrium (G), some of which are localized to regions previously shown to contain macrophages.59 (I, J) Ovary of transgenic mice, showing β-galactosidase expression in granulosa cells surrounding the secondary follicles (SF). Bars: (A-D) 5 mm; (E-J) 50 mm.