Fig. 2.
Treatment of PBMCs with Thal and IMiDs increases MM cell line lysis.
Lysis of the MM cell line HS Sultan by normal PBMCs treated with IL-2 for 72 hours and then by Thal or IMiDs for 72 hours was measured using a standard 51Cr release assay at 30:1 to 7.5:1 effector-target ratios. Results are representative of 3 independent experiments. (A) Effect of Thal and IMiD1, IMiD2, and IMiD3 at 1 μg/mL. (B) (upper panel) Effect of Thal (1 μg/mL and 5 μg/mL). (lower panel) Effect of IMiD1 (1 μg/mL and 5 μg/mL). (C) PBMCs treated with and without the addition of exogenous IL-2 followed by the addition of Thal/IMiD1 (5 μg/mL).
