Effect of bone marrow reconstitution with IL-1Ra on renal function after the induction of anti-GBM glomerulonephritis.

The bone marrow of female recipients was reconstituted with male cells, which possessed the mouse IL-1Ra gene (IL-1Ra chimera) or human GC gene (GC chimera). Anti-GBM glomerulonephritis was induced in these chimeric mice (10 per group), and serum creatinine levels (left) and urea nitrogen levels (right) were measured before and 28 days after the induction. Data are presented as means ± SE. Asterisks indicate significant differences (P < .05) between the 2 groups.