Histology of kidney after nephritis induction in IL-1Ra and GC chimera (day 28).

Kidney sections from nephritis-induced chimeric mice were subjected to PAS staining. (A,C) GC chimera; (B,D) IL-1Ra chimera (original magnification: × 400 for panels A and B, × 100 for panels C and D). (E) To semiquantify the severity of glomerular damage, relative amounts of glomerular staining of type I collagen (i), laminin (ii), and fibrinogen (iii) were scored as described in “Materials and methods.” Data are shown as means ± SE. Asterisks indicate significant differences (P < .05) between the 2 groups.