Percentage tetramer⁺ EBV-specific T cells and functionality of tetramer⁺ T cells in HIV⁻and HIV⁺ individuals.

(A) The number of tetramer⁺ (percentage of CD8⁺T cells as assessed by tetramer staining) and (B) proportion of IFN-γ–producing T cells of tetramer⁺ T cells (percentage of tetramer⁺ T cells determined after peptide stimulation) are shown for HIV⁻ (n = 6, filled circles) and HIV⁺ individuals (n = 11) early in HIV infection (average of time points studied until CD4⁺ T cells drop below 200/μL or halfway through follow-up). HIV⁺ individuals include individuals progressing to AIDS-NHL (n = 5, open triangles) or AIDS-OI (n = 3, open circles) and LTA HIV-infected individuals (n = 3, filled triangles).