EBV-specific T cells and EBV load early and late in HIV-1 infection.

For 3 groups of HIV-infected individuals, from the longitudinal data the average of early (period studied until CD4⁺ T cells drop below 200/μL or halfway through follow-up) and late (average of time points from the drop in CD4⁺ T cells below 200/μL or halfway through follow-up until AIDS diagnosis or last time point studied) time points in HIV-infection were calculated excluding time periods on therapy. For AIDS-NHL patients (left), LTA individuals (middle), and AIDS-OI patients (right), the figure depicts (A) the percentage of EBV tetramer⁺ CD8⁺ T cells, (B) the number of IFN-γ–producing EBV-specific T cells per 10⁶ CD8⁺ T cells, (C) the proportion of IFN-γ⁺ tetramer⁺ T cells, and (D) EBV load per 10⁶ PBMCs.