HIV-infected donors have few CCR7⁺naı̈ve (CCR7⁺CD45RA⁺) or long-term memory (CCR7⁺CD45RA⁻) CD8 T cells but compensate with expansions of effector (CCR7⁻CD45RA⁺) and effector memory (CCR7⁻CD45RA⁻) cells.

(A) Representative dot plots of gated CD8^bright lymphocytes from healthy donors and HIV-infected donors classified according to disease stages determined in 1993 by the CDC.32 (B) Summary of CCR7 and CD45RA costaining data from healthy donors and HIV-infected donors. The proportion of CCR7⁺ naı̈ve and long-term memory cells was lowest in patients with stage C AIDS. The differences between healthy donors and HIV-infected donors are significant.