Fig. 7.
Fig. 7. The combination of JAQ1 and adrenaline or ADP induces αIIbβ3 activation. / (A) Flow cytometric quantitation of fibrinogen binding to wild-type (▪) and Gαq-deficient (■) platelets stimulated with ADP (5 μM) or adrenaline (10 μM) in the presence or absence of JAQ1 (10 μg/mL). (B) Washed wild-type platelets were incubated with JAQ1 (10 μg/mL) and then activated with ADP (5 μM) or adrenaline (10 μM) in the absence or presence of the blocking antimouse αIIbβ3 mAb RAM.2 (1/10 dilution of ascites fluid).

The combination of JAQ1 and adrenaline or ADP induces αIIbβ3 activation.

(A) Flow cytometric quantitation of fibrinogen binding to wild-type (▪) and Gαq-deficient (■) platelets stimulated with ADP (5 μM) or adrenaline (10 μM) in the presence or absence of JAQ1 (10 μg/mL). (B) Washed wild-type platelets were incubated with JAQ1 (10 μg/mL) and then activated with ADP (5 μM) or adrenaline (10 μM) in the absence or presence of the blocking antimouse αIIbβ3 mAb RAM.2 (1/10 dilution of ascites fluid).

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal