Dipyridamole inhibition of sickling-induced fluxes of Na⁺ and K⁺.

Net fluxes were measured in 2-hour incubations at 2% hematocrit in the presence of the nominal concentrations of drug indicated. The sickling-induced flux was calculated as the difference in flux rates under oxygenated and deoxygenated conditions. Sickling-induced flux values in each experiment were normalized to the uninhibited control flux, which ranged from 14.7 to 35.1 mmol/kg Hb per hour in this set of 8 experiments from 6 individuals. Data points represent the mean (with SD) of these normalized values. ●, Na⁺ influx; ▪, K⁺ efflux.