Fig. 1.
Increase in erythrocyte number in spleen of anti-CD147–treated mice coincides with decrease in hematocrit.
DBA2 mice were injected intraperitoneally with 100 μg RL73 F(ab′)2 (▪)or Ter119 F(ab′)2 (●) and mice were killed on days 2, 4, 7, 11, and 16. Spleen cells were weighed (A), and analyzed by FACS (B). The erythrocyte/lymphocyte ratio reflects the percentage of Ter119+VLA-4− erythrocytes divided by the combined percentage of CD4+, CD8+, and B220+ cells. Hematocrit (C) was measured by standard methods at the indicated time points following RL73 F(ab′)2 or Ter119 F(ab′)2 treatment.
