Fig. 1.
Impact of route of administration of AAV-hFIX on hFIX expression.
Increasing doses, 2 × 109 vp, 2 × 1010vp, and 2 × 1011 vp of AAV-hFIX were administered to C57Bl/6 mice via cannulization of the portal vein or by direct injection into the quadriceps muscle. Sera were harvested from the animals 11 (gray bars), 25 (white bars), and 41 (black bars) days after vector administration and analyzed for the presence of hFIX (upper panels) and anti-hFIX antibodies (bottom panels).
