Fig. 3.
Fig. 3. FISH analysis of TEL-AML1 fusion and TELdeletion. / Representative cells from T1 (2 metaphases, 3 interphases). The lower left-hand metaphase shows 2 normal signals each for TEL(green) and AML1 (red) with no fusion gene (juxtaposition of 2 colors)—ie, a normal, nonleukemic cell. The right-hand metaphase shows a red–green TEL-AML1 fusion plus the normal and the split AML1 signals. In this cell, the green TELsignal (for the nonrearranged TEL allele) is missing (ie, deleted) from the second chromosome 12. The lower interphase cell similarly has TEL-AML1 fusion plus TEL deletion. In contrast, the upper interphase cell has TEL-AML1 fusion but retains the second TEL (green) allele. The middle interphase cell has normal TEL and AML1 signals (note: in this latter, nonleukemic cell, one TEL and oneAML signal are in proximity but are not overlapping or fused).

FISH analysis of TEL-AML1 fusion and TELdeletion.

Representative cells from T1 (2 metaphases, 3 interphases). The lower left-hand metaphase shows 2 normal signals each for TEL(green) and AML1 (red) with no fusion gene (juxtaposition of 2 colors)—ie, a normal, nonleukemic cell. The right-hand metaphase shows a red–green TEL-AML1 fusion plus the normal and the split AML1 signals. In this cell, the green TELsignal (for the nonrearranged TEL allele) is missing (ie, deleted) from the second chromosome 12. The lower interphase cell similarly has TEL-AML1 fusion plus TEL deletion. In contrast, the upper interphase cell has TEL-AML1 fusion but retains the second TEL (green) allele. The middle interphase cell has normal TEL and AML1 signals (note: in this latter, nonleukemic cell, one TEL and oneAML signal are in proximity but are not overlapping or fused).

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