Fig. 9.
![Fig. 9. Model depicting the dual regulation by MLC kinase and myosin phosphatase of myosin phosphorylation in platelet secretion. / [Ca2+]i indicates intracellular Ca++ concentration; CPI- P○, phosphorylated CPI; DG, diacylglycerol; Ins(1,4,5)P3, inositol 1,4,5-triphosphate; GF109203X, inhibitor of PKC; MBS- P○, phosphorylated MBS at Thr696; MLC20- P○, phosphorylated MLC20 at Ser19; PKN, protein kinase N; PLC, phospholipase C; GEF, Rho-specific guanine nucleotide exchange factor; Y-27632, inhibitor of Rho-kinase.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/12/10.1182_blood.v97.12.3798/6/h81211168009.jpeg?Expires=1735544616&Signature=wmL12fNOxzE77pHpSI5Cz1QU7csfsKKYZmI88uRCxBvTAEw6lleDPcDkh3vl-YWe~7sbV5seTERXBwsiKXEPeHHgA8fpBDJ~uxI6EAsFlvFalrdNDp43TUY-d839S66T8Hg1Yo3AHB2oJ~xe-t4QIxB9Cf0~FjFslcw0y6l1tAqIZDbzHIFLYv3oCuZPL0yOtJReTanmIsxbbxwIs9K4DEXES~Pon~68kN~tproWZWz53W92lVSdFSz3nvuWc6k-egcMHBYZm6-lN4U1cnNm5pK38tMRXfrYiA62IK6JEhyPXY0nsbkjlDGqnjZe~gXR7WJ0162Dn-an2goHZ0asLg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Model depicting the dual regulation by MLC kinase and myosin phosphatase of myosin phosphorylation in platelet secretion.
[Ca2+]i indicates intracellular Ca++ concentration; CPI- P○, phosphorylated CPI; DG, diacylglycerol; Ins(1,4,5)P3, inositol 1,4,5-triphosphate; GF109203X, inhibitor of PKC; MBS- P○, phosphorylated MBS at Thr696; MLC20- P○, phosphorylated MLC20 at Ser19; PKN, protein kinase N; PLC, phospholipase C; GEF, Rho-specific guanine nucleotide exchange factor; Y-27632, inhibitor of Rho-kinase.
