GST-CD34ifull fusion protein.
The native CD34 protein contains 23 transmembrane and 73 intracellular amino acids in addition to the extracellular domain. Depicted is the amino acid sequence of CD34 that was expressed as a GST-fusion protein in studies designed to precipitate CD34 interacting protein(s). This region includes roughly half the transmembrane domain (parentheses) and all of the intracellular domain of full-length CD34. Listed below is a comparison of the predicted amino acid sequences of human, murine, and canine CD34, demonstrating the high degree of conservation between species. Amino acids differing between species are enlarged. Depicted on the bottom line is the corresponding sequence of truncated CD34. Note that the first 12 intracellular amino acids are 100% conserved between species.
