Fig. 4.
Clinical signs of GVD in recipients of B6-cdd CD4 T cells.
Recipients of B6-cdd CD4 T cells exhibited clinical signs of GVHD (weight loss, diarrhea, fur texture, posture, and alopecia). Clinical changes (maximum score, 10) associated with GVHD were assessed by means of a scoring system described in “Materials and methods.” Recipients of 5 × 106 B6-cdd CD4+ T cells exhibited a clinical score of 8 within 21 days of BMT (data not shown). ▪, 2.5 × 106 B6; ▾, 0.25 × 106 B6; ■, 2.5 × 106 B6-cdd; ▿, 0.25 × 106B6-cdd donor CD4+ T cells.
