Fig. 1.
Saturation curves for DiOC6.
(A). Time-course saturation curves for DiOC6 (MFI, mean fluorescence intensity on an arbitrary scale) in the MDR-negative HL60 (squares), pgp-positive KG1a (diamonds), and MRP-positive HL60/ADR (triangles) cell lines. The MDR-positive cell lines were chosen to determine whether drug-efflux pumps altered the saturation plateau for DiOC6. (B) Time-course saturation curves for DiOC6 in the presence (solid symbols) and absence (open symbols) of 125 mM potassium chloride in 3 primary leukemia samples.
