Fig. 9.
Inhibition of depolarization and apoptosis by MBB.
Flow cytometric histograms for DiOC6 and PI staining of the CEM C7H2 cell or its daughter cell CEM 4G5, whose mutant TP53 adopts a wild-type conformation when cultured at the permissive temperature (32°C). The cells were cultured for 18 hours with or without 4.5 μM MBB. Percentages of depolarized (DiOC6-low) cells or cells with less DNA than the G0/G1 peak (PI-low cells) are indicated on the histograms. Results are representative of 3 similar experiments.
