The iron chelator 311 is more effective than DFO at decreasing the expression of the cyclins A, B1, D1, D2, and D3 and increasing the expression of cyclin E.

SK-N-MC cells were incubated with DFO (5-150 μM) or 311 (1-25 μM) for 30 hours at 37°C, and the cells were harvested. Western blot analysis was then performed as described in “Materials and methods.” Results shown are representative of 3 separate experiments performed.