Comparison of the homologous domains in the flanking regions of the PBP/PF4 locus.

A comparison of the conserved regions, other than within the coding areas or the immediate 1.0 kb of 5′-flanking region, of the mouse and human PBP and PF4 genes are shown. A “‖” refers to an identical nucleotide. Consensus DNA binding sites for a number of megakaryocyte-specific transcriptional factors are highlighted and the names of the transcriptional factors and their orientations are shown. Panel A represents the conserved domain upstream of the PBP gene, and negative numbering begins at the PBP transcriptional start site.11 Panel B represents the conserved intergenic region, and negative numbering begins at the PF4 transcriptional start site.10 Panel C represents the conserved region downstream of the PF4 gene, and numbering begins at the PF4 transcriptional start site.