Platelet response to 5-FU in eusplenic and splenectomized mice.

(A) Comparison of platelet response to administration of 5-FU (150 mg/kg) in eusplenic c-mpl^−/− mice (▵) and splenectomized c-mpl^−/− (●) mice. Elevation of platelet counts in splenectomized c-mpl^−/− mice was greater than that in eusplenic c-mpl^−/− mice, and the counts were higher than normal. (B) Response in eusplenic C57/Bl6 mice (▵) and splenectomized C57/Bl6 mice (●). Mice were given injections of 5-FU 5 weeks after splenectomy. Baseline platelet counts were obtained before injection. Data are based on a total of 20 mice analyzed in each group.