Dose-response inhibitory effect of the p38 MAPK inhibitor SB203580 on thrombin-induced IL-8 and MCP-1 production.

HUVECs cultured with or without increasing concentrations of the specific p38 MAPK inhibitor SB203580 for 1 hour were then stimulated with thrombin (8 U/mL) for 24 hours. Chemokines were measured in the supernatants IL-8 (A) and MCP-1 (B); *P < .01, **P < .001, ***P < .05 compared with thrombin alone (n = 6).