Kinetics of thrombin-induced IL-8 and MCP-1 production: effects of SB203580.

HUVECs were preincubated without (▪) or with SB203580 (2 μM) (■) for 1 hour and then stimulated with 8 U/mL thrombin for various times before chemokines were measured in the supernatants IL-8 (A) and MCP-1 (B); *P < .05, **P < .01 compared with thrombin alone (n = 3), unstimulated HUVECs (○).