Fig. 1.
![Fig. 1. Correlations of pretreatment blast cell Pgp surface expression and Pgp function. / Pgp surface expression, as determined by the immunofluorescence staining intensity ratio using the antibody 4E3.16, correlated significantly with Pgp function, as indicated by the efflux ratio of the Pgp substrate dye DiOC2 in the 36 patient samples where dye efflux was inhibited to levels greater than or equal to 50% by CSA (black circles). In comparison, surface expression of Pgp correlated poorly with the baseline dye efflux ratio in the 23 patient samples that were insensitive to CSA inhibition (ie, < 50% inhibition of efflux [white circles]) despite exhibiting elevated levels of baseline efflux at or above the levels of samples that were sensitive to CSA.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/98/4/10.1182_blood.v98.4.988/6/h81611429001.jpeg?Expires=1735572256&Signature=h2AOS-nHsO4PC6SmfvsWHMYNzgyLCd2RG6Zw8DIWWwqfJVsn6Cf-h4EcVoYdFvGU8a8lbh8Bk2CTMOWEhuoAa6MwEZTpM1gVQ2o5~Wd3BQSE0CPqNYky-USvW44uls8mMJ2sn~CWUD7JcqvJgfblJWEyt~F7-6K~~pQEfzImBg5cS1~yoalaaVtnF7DiAcybBdNQTxSPgN5HzRSiWIlIRPhsY9OF8Hx78WS7hWxpPiGWxfT606~pQ4RQ6sP8EcxWQjz7sFVlh75lPED~BjI7OLDOuilGXRHoyAU0sIF-wSCOs-a~ZG6uD2nABg1GwpiffitEB3dmKUnHM5IvHng-RA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Correlations of pretreatment blast cell Pgp surface expression and Pgp function.
Pgp surface expression, as determined by the immunofluorescence staining intensity ratio using the antibody 4E3.16, correlated significantly with Pgp function, as indicated by the efflux ratio of the Pgp substrate dye DiOC2 in the 36 patient samples where dye efflux was inhibited to levels greater than or equal to 50% by CSA (black circles). In comparison, surface expression of Pgp correlated poorly with the baseline dye efflux ratio in the 23 patient samples that were insensitive to CSA inhibition (ie, < 50% inhibition of efflux [white circles]) despite exhibiting elevated levels of baseline efflux at or above the levels of samples that were sensitive to CSA.
