DNA sequence analysis of exons 51 and 52 of the

VWF gene in WT and affected members of families 1, 2, and 3. Panel A shows the WT sequence of exon 51 from T8434 to T8457, with an arrow indicating nt 8437 where the deletion begins in patient F3P1. Panel B shows the DNA sequence of the patient from family 3, with a series of superimposed bases as a result of the heterozygous deletion beginning at position 8437. Panels C to E show the sequence of exon 52 from nucleotide 8555 to 8571. Panel C shows the WT sequence. Panel D shows the sequence from one affected member from family 1, with a heterozygous G8562A transition. Panel E shows the sequence from patient F2P2, showing a T8561A transversion.