Fig. 5.
Effects of blocking HB-EGF in the XG-1 HMCL.
XG-1 (A,B) or EBV-1 (C) cells were cultured at 105cells/well for 4 days in RPMI 1640 medium with 10% FCS, IL-6 (3 ng/mL), and graded concentration of neutralizing anti–HB-EGF antibody (μg/mL). In some culture groups, recombinant HB-EGF (1 μg/mL) was used to reverse the inhibitory effects of the anti–HB-EGF antibody. Results are mean values ± SD of triplicate wells and are representative of 3 independent experiments.
