Effects of aspirin on collagen-induced aggregation of WT and GPV-deficient platelets.

Washed mouse platelets left untreated or preincubated with 10 mM aspirin (ASA) were activated with 0.625 μg/mL collagen (Coll) in the presence of fibrinogen. Aspirin inhibited the aggregation response of both GPV null (−/−) and WT (+/+) platelets, but a more prolonged lag phase was observed in GPV-deficient cells. This experiment was performed twice with comparable results.