Map of the calmodulin-binding subunits of the GPIb-IX-V complex.

(A) Cytoplasmic domain of GPIbβ17 showing sequences that interact with calmodulin (this study), and the RXSXTXP motif that interacts with 14-3-3ζ.13 The asterisk indicates the phosphorylation site at S166.35 The structure of GPIbβ is compared with that of GAP-43.31,32 (B) Schematic representation of GPIb-IX-V showing locations of sequences that bind calmodulin (this study), 14-3-3ζ,12-14 and actin-binding protein.36 37