Fig. 5.
Hypocellularity and increased fat accumulation in Fancc−/−Sod1−/−BM.
Metaphyseal sections of leg bones fromFancc+/+Sod1+/+(A),Fancc−/−(B), Sod1−/−(C), and Fancc−/−Sod1−/−(D) mice (magnification × 400). Marrow fat content (clear areas) is increased in Fancc−/−Sod1−/−mice compared with Fancc+/+ Sod1+/+ or toFancc−/−. Controls revealed only rare fat cells,whereas Sod1−/−mice did show some increase in fat spaces.