Fig. 8.
Immature DCs generated by GM-CSF plus IL-4 in the presence of IFN-α undergo apoptosis in response to a variety of activation stimuli.
The response of immature DCs generated in the permanent presence of 1000 U/mL IFN-α (▪) to the indicated stimuli was compared with that of immature DCs generated in the absence of IFN-α (░). Apoptosis was quantified on day 8 (ie, 3 days after activation with 1 μg/mL LTA, 100 ng/mL LPS, 100 ng/mL LPS plus 1000 U/mL IFN-γ, and 1000 U/mL TNF-α plus 1 μg/mL PGE2 as indicated [mean ± SD of 3 independent experiments]).