Effect of IVIG in antibody-mediated thrombocytopenia after intraperitoneal injection.

Immune thrombocytopenia after intraperitoneal injection of antiplatelet mAb MWReg30. Time-course of mean platelet counts (± SEM) is shown after injection of MWReg30 at t = 0 minute. Mice were pretreated with aged IVIG (▪), fresh IVIG (▾), or saline (■) 1 hour before MWReg30 at a dose of 1 g/kg. Injection of aged IVIG alone, without subsequent injection of the antiplatelet mAb (○), was used as a control. Results are expressed as mean of 6 experiments ± SEM on different occasions. The aged IVIG preparation used in the experiment was stored at 4°C for 1 year. Asterisks indicate statistically significant differences compared to saline control (*P < .05; **P < .01).