Anti-GVHD activity of the JAK3 inhibitor WHI-P131.

(A.1, A.2) Histopathologic examination of the liver from the representative vehicle-treated control C57BL/6 (H-2^b) mouse transplanted with a BALB/c (H-2^d) BM/S graft, killed on day 30 after BMT, revealed a severe, predominantly lymphocytic, inflammatory reaction around the portal area with destruction of bile ducts. (A.3) Skin GVHD with focal pyknotic cells and vacuolation in the basal cell layer of the epidermis in skin of the same mouse. (B.1, B.2) Histopathologic examination of the liver from the representative WHI-P131–treated C57BL/6 (H-2^b) mouse transplanted with a BALB/c (H-2^d) BM/S graft, killed on day 30 after BMT, revealed a mild lymphocytic infiltration of the portal area without a bile duct infiltration and destruction. (B.3) Normal-appearing skin in the same mouse.