Composite N-terminal sequence of vWF-cleaving protease.

The sequence is derived from sequential Edman degradation and translation from genomic (Genbank gi 12733516) and EST (3841323) sequences. Residues determined in part by Edman degradation are boxed. Residues 150 to 161, containing the extended active site sequence of metalloproteinases of the ADAMTS subfamily, are double-underlined. Residues −1 to −4, corresponding to a putative furin-processing site at the C terminus of the precursor form, is underlined.