Effect of sLeX tetrasaccharide on the adherence of nonsickle and sickle erythrocytes to HUVECs treated with or without thrombin.

The data shown are the static adherence of RBCs to HUVEC that were treated with thrombin or medium alone. The 100% adherence is the mean number of nonsickle (AA) RBCs/field adherent to untreated HUVECs. SS, sickle erythrocytes. The reduction of erythrocyte adherence to untreated or thrombin-treated HUVECs in the presence of sLac () or sLeX (▪) tetrasaccharide is shown. ■, control. The data are mean percent adherence from 4 replicate experiments. Significant inhibition of adherence due to sLeX with P < .05 is denoted by *.