Schematic representation of FX chimera constructs.

There are 8 recombinant chimeric proteins. The protein domains are as follows: γ-carboxy glutamic acid rich (Gla), epidermal growth factor-like (EGF1 and EGF2), activation peptide (AP), and protease. FX and domains of FX are in white, whereas FIX domains are in black. Within the chimeras, numbers indicate the specific adjacent residues from FIX and FX that comprise the exchange sites.